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Centre of Chronic Immunodeficiency, University Hospital Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany. Jan.Thoden@uniklinik-freiburg.de
We present a rare case of hemophagocytic lymphohistiocytosis (HLH) in a 70 year-old male patient with previously well-controlled HIV infection. We could confirm HLH in different organs post mortem. Since the diagnosis of HLH was delayed, the patient died despite initiation of chemotherapy. As cause for HLH, an EBV reactivation could be confirmed. In HIV infection, HLH may be the first HIV manifestation, often triggered by an opportunistic infection or immune reconstitution syndrome, but it is uncommon in the state of a well-controlled or aviremic HIV infection.
Copyright © 2011 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
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