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J Biophotonics. 2011 Sep;4(9):583-7. doi: 10.1002/jbio.201000103. Epub 2010 Dec 17.

Correlation mapping method for generating microcirculation morphology from optical coherence tomography (OCT) intensity images.

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  • 1University of Limerick, Department of Physics, Castletroy, Limerick, Ireland. enock.jonathan@ul.ie


Standard optical coherence tomography (OCT) in combination with software tools can be harnessed to generate vascular maps in vivo. In this study we have successfully combined a software algorithm based on correlation statistic to reveal microcirculation morphology on OCT intensity images of a mouse brain in vivo captured trans-cranially and through a cranial window. We were able to estimate vessel geometry at bifurcation as well as along vessel segments down-to mean diameters of about 24 μm. Our technique has potential applications in cardiovascular-related parameter measurements such as volumetric flow as well as in assessing vascular density of normal and diseased tissue.

Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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