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J Biophotonics. 2011 Sep;4(9):583-7. doi: 10.1002/jbio.201000103. Epub 2010 Dec 17.

Correlation mapping method for generating microcirculation morphology from optical coherence tomography (OCT) intensity images.

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  • 1University of Limerick, Department of Physics, Castletroy, Limerick, Ireland.


Standard optical coherence tomography (OCT) in combination with software tools can be harnessed to generate vascular maps in vivo. In this study we have successfully combined a software algorithm based on correlation statistic to reveal microcirculation morphology on OCT intensity images of a mouse brain in vivo captured trans-cranially and through a cranial window. We were able to estimate vessel geometry at bifurcation as well as along vessel segments down-to mean diameters of about 24 μm. Our technique has potential applications in cardiovascular-related parameter measurements such as volumetric flow as well as in assessing vascular density of normal and diseased tissue.

Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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