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Cell. 2011 Sep 2;146(5):669-70. doi: 10.1016/j.cell.2011.08.019.

A new FOXO pathway required for leukemogenesis.

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  • 1Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. james.downing@stjude.org

Abstract

In cancer, the FOXO family of transcription factors functions as tumor suppressors and is directly inactivated by oncogenic signaling through the PI3K/AKT pathway. Now, Skykes et al. (2011) identify a paradoxical requirement for FOXOs in the maintenance of leukemia-initiating cells.

Copyright © 2011 Elsevier Inc. All rights reserved.

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