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Cell. 2011 Sep 2;146(5):669-70. doi: 10.1016/j.cell.2011.08.019.

A new FOXO pathway required for leukemogenesis.

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  • 1Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.


In cancer, the FOXO family of transcription factors functions as tumor suppressors and is directly inactivated by oncogenic signaling through the PI3K/AKT pathway. Now, Skykes et al. (2011) identify a paradoxical requirement for FOXOs in the maintenance of leukemia-initiating cells.

Copyright © 2011 Elsevier Inc. All rights reserved.

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