Biochim Biophys Acta. 2011 Nov;1814(11):1567-76. Epub 2011 Jul 24.

PLP-dependent enzymes as potential drug targets for protozoan diseases.

Kappes B, Tews I, Binter A, Macheroux P.

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University Hospital Heidelberg, Department of Infectious Diseases, Parasitology, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany.

Abstract

The chemical properties of the B(6) vitamers are uniquely suited for wide use as cofactors in essential reactions, such as decarboxylations and transaminations. This review addresses current efforts to explore vitamin B(6) dependent enzymatic reactions as drug targets. Several current targets are described that are found amongst these enzymes. The focus is set on diseases caused by protozoan parasites. Comparison across a range of these organisms allows insight into the distribution of potential targets, many of which may be of interest in the development of broad range anti-protozoan drugs. This article is part of a Special Issue entitled: Pyridoxal Phosphate Enzymology.

PMID:: 21884827; [PubMed - indexed for MEDLINE]

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