Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Traffic. 2012 Feb;13(2):195-203. doi: 10.1111/j.1600-0854.2011.01268.x. Epub 2011 Sep 19.

Spatial guidance of cell asymmetry: septin GTPases show the way.

Author information

  • 1Department of Biology, Drexel University, Philadelphia, PA 19104, USA. ets33@drexel.edu

Abstract

Eukaryotic cells develop asymmetric shapes suited for specific physiological functions. Morphogenesis of polarized domains and structures requires the amplification of molecular asymmetries by scaffold proteins and regulatory feedback loops. Small monomeric GTPases signal polarity, but how their downstream effectors and targets are spatially co-ordinated to break cell symmetry is poorly understood. Septins comprise a novel family of GTPases that polymerize into non-polar filamentous structures which scaffold and restrict protein localization. Recent studies show that septins demarcate distinct plasma membrane domains and cytoskeletal tracks, enabling the formation of intracellular asymmetries. Here, we review these findings and discuss emerging mechanisms by which septins promote cell asymmetry in fungi and animals.

© 2011 John Wiley & Sons A/S.

PMID:
21883761
[PubMed - indexed for MEDLINE]
PMCID:
PMC3245886
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Blackwell Publishing Icon for PubMed Central
    Loading ...
    Write to the Help Desk