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Dtsch Med Wochenschr. 2011 Sep;136(36):1770-6. doi: 10.1055/s-0031-1286099. Epub 2011 Aug 31.

[Clinical symptoms, treatment and outcome of EHEC and EHEC-HUS patients treated as in-patients].

[Article in German]

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  • 1III. Medizinische Abteilung (Gastroenterologie, Hepatologie), Asklepios Klinik Barmbek, Hamburg.

Abstract

BACKGROUND AND OBJECTIVE:

From May to June 2011 an outbreak of Shiga-toxin-producing Escherichia coli (EHEC) infections occurred in northern Germany leading to a great number of patients with hemolytic-uremic syndrome (HUS). A monocentric case series from Hamburg is described.

MATERIAL AND METHODS:

All patients at that time presenting with acute diarrhoea at the Asklepios Clinic Barmbek in Hamburg were proved for EHEC infections. Clinical data of EHEC and EHEC-HUS patients treated as in-patients as well as stool analysis and laboratory results were documented.

RESULTS:

In total, 117 patients suspicious to have EHEC infection were treated as in-patients. In 68 patients an EHEC infection (n = 36) or HUS (n = 32) could be confirmed. Additional infections with other diarrhoea-causative organism could be revealed in 23 of these 68 patients (34 %). The median age of the HUS patients was 44 years being significantly lower compared to the age of EHEC patients without HUS (51 years, p = 0,04). In the group of HUS patients there were significantly more women (26/32 vs. 21/36, p = 0.03). 19 patients with HUS dialysis was necessary. In total, a number of 248 plasma separations were required. 18 patients developed severe neuro-psychiatric symptoms. One patient died.

CONCLUSION:

This monocentric case series describes one of the so far largest published series of mostly young and female patients with EHEC and EHEC-HUS.

Georg Thieme Verlag KG Stuttgart · New York.

[PubMed - indexed for MEDLINE]
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