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J Clin Microbiol. 2011 Nov;49(11):3931-3. doi: 10.1128/JCM.01176-11. Epub 2011 Aug 31.

Accuracy of carbapenem nonsusceptibility for identification of KPC-possessing Enterobacteriaceae by use of the revised CLSI breakpoints.

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  • 1Division of Infectious Diseases, SUNY-Downstate, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.


Using the updated 2010 CLSI carbapenem breakpoints for the Enterobacteriaceae, nonsusceptibility to ertapenem and imipenem predicted the presence of bla(KPC) poorly, especially among Escherichia coli and Enterobacter species. In regions where KPC-producing bacteria are endemic, testing for nonsusceptibility to meropenem may provide improved accuracy in identifying these isolates.

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