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Cold Spring Harb Protoc. 2011 Sep 1;2011(9). pii: pdb.top065581. doi: 10.1101/pdb.top065581.

Gene set analysis and network analysis for genome-wide association studies.

Abstract

The application of high-throughput genotyping in humans has yielded numerous insights into the genetic basis of human phenotypes and an unprecedented amount of genetic data. Genome-wide association studies (GWAS) have increased in number in recent years, but the variants that have been found have generally explained only a tiny proportion of the estimated genetic contribution to phenotypic variation. This article summarizes the progress made in the development of gene set analysis (GSA) and network analysis for GWAS was a way to identify the underlying molecular processes of human phenotypes. It also highlights some promising findings and indicates future directions that may greatly enhance the analysis and interpretation of GWAS.

PMID:
21880815
[PubMed - indexed for MEDLINE]
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