Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Mayo Clin Proc. 2011 Sep;86(9):885-93. doi: 10.4065/mcp.2011.0332.

Perioperative cognitive decline in the aging population.

Author information

  • 1Department of Anesthesia and Perioperative Care, San Francisco, CA 94143-0648, USA.

Abstract

Elderly patients who have an acute illness or who undergo surgery often experience cognitive decline. The pathophysiologic mechanisms that cause neurodegeneration resulting in cognitive decline, including protein deposition and neuroinflammation, also play a role in animal models of surgery-induced cognitive decline. With the aging of the population, surgical candidates of advanced age with underlying neurodegeneration are encountered more often, raising concerns that, in patients with this combination, cognitive function will precipitously decline postoperatively. This special article is based on a symposium that the University of California, San Francisco, convened to explore the contributions of surgery and anesthesia to the development of cognitive decline in the aged patient. A road map to further elucidate the mechanisms, diagnosis, risk factors, mitigation, and treatment of postoperative cognitive decline in the elderly is provided.

Comment in

PMID:
21878601
[PubMed - indexed for MEDLINE]
PMCID:
PMC3257991
Free PMC Article

Images from this publication.See all images (1)Free text

FIGURE.
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk