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Cell Mol Life Sci. 2012 Jan;69(2):191-201. doi: 10.1007/s00018-011-0804-5. Epub 2011 Aug 30.

Spectrin-based skeleton as an actor in cell signaling.

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  • 1University of Zielona Góra, Zielona Góra, Poland.

Abstract

This review focuses on the recent advances in functions of spectrins in non-erythroid cells. We discuss new data concerning the commonly known role of the spectrin-based skeleton in control of membrane organization, stability and shape, and tethering protein mosaics to the cellular motors and to all major filament systems. Particular effort has been undertaken to highlight recent advances linking spectrin to cell signaling phenomena and its participation in signal transduction pathways in many cell types.

PMID:
21877118
[PubMed - indexed for MEDLINE]
PMCID:
PMC3249148
Free PMC Article

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