Compr Psychiatry. 1990 May-Jun;31(3):261-5.

The combination of lithium and carbamazepine in treatment and prevention of manic-depressive disorder: a review and a case report.

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Department of Psychiatry, University of Aarhus, Psychiatric Hospital, Risskov, Denmark.

Abstract

The action of carbamazepine (CZP) is similar to that of lithium with regard to therapeutic effect towards mania; in addition, it has a certain effect towards endogenous depression. Furthermore, CZP has a prophylactic effect towards manic-depressive mood swings, although probably not as expressed as that of lithium. In some cases, especially in rapid-cyclers, neither CZP nor lithium have this effect when applied separately, whereas the combination of the two drugs is effective in some cases. A review of the relevant literature, as well as an illustrative case history, is presented.

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