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J Org Chem. 2011 Oct 7;76(19):8042-8. doi: 10.1021/jo2011957. Epub 2011 Aug 29.

Diversity-oriented synthesis of 13- to 18-membered macrolactams via ring-closing metathesis.

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  • 1Chemical Biology Platform, Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, United States.


An efficient build/couple/pair approach to diversity-oriented synthesis was employed to access several structurally complex macrolactams. In this paper, we describe the successful evaluation of ring-closing metathesis toward the systematic generation of skeletal diversity. By appropriately varying the nature and chain length of the alkenol fragment, a diverse collection of 13- to 18-membered macrolactams were obtained.

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