Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Transfus Med Rev. 2012 Apr;26(2):164-80. doi: 10.1016/j.tmrv.2011.07.006. Epub 2011 Aug 26.

Blood transfusion safety in Africa: a literature review of infectious disease and organizational challenges.

Author information

  • 1Blood Systems Research Institute, San Francisco, CA 94118, USA. ebloch@bloodsystems.org

Abstract

Blood safety remains an important public health concern in Africa where lack of availability or provision of unsafe blood adversely impacts morbidity and mortality in the region. In recognition of this shortfall, the World Health Organization (WHO) established a goal of regional blood safety by 2012 through improved "organization and management, blood donor recruitment and collection, testing of donor blood as well as appropriate clinical use of blood" (Tagny et al: Transfusion. 2008;48:1256-1261; Tapko et al: Status of Blood Safety in the WHO African Region: Report of the 2006 Survey http://www.afro.who.int/en/divisions-a-programmes/dsd/health-technologies-a-laboratories.html. Brazzaville, Republic of Congo: WHO Regional Office for Africa; 2006). Although there has been substantial progress toward meeting these objectives, there are continued obstacles to both development and sustainability. In a setting where transfusion oversight is still being improved, transfusion-transmitted infections are of real concern. The high prevalence of some transfusion-transmissible agents such as hepatitis B virus and HIV in the general population means that some infected blood units escape detection by even well-performed laboratory testing, resulting in potential downstream transmission to patients. The spectrum of transfusion-transmitted infection include conventional as well as exotic pathogens, many of which are endemic to the region, thereby imparting ongoing challenges to recruitment and testing strategies.

Copyright © 2012 Elsevier Inc. All rights reserved.

PMID:
21872426
[PubMed - indexed for MEDLINE]
PMCID:
PMC3668661
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk