Abstract
The novel gene GDDR, also named trefoil factor interactions 1, is abundantly expressed in human gastric epithelial cells but significantly down-regulated in gastric cancer. In this study, we first demonstrated that GDDR was specifically expressed in the gastrointestinal tract epithelium, while suppressed in gastric cancer cells. Forced expression of GDDR suppressed the tumor growth as shown by MTT and xenograft assay. siRNA mediated TFF1 inhibition nearly blocked the growth inhibitory role of GDDR. In summary, our study suggested that gastrointestinal tract specific gene GDDR might inhibit gastric cancer growth in a TFF1 dependent manner.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Carrier Proteins / analysis
-
Carrier Proteins / physiology*
-
Cell Proliferation
-
Cell Survival
-
Disease Progression
-
Epithelium / chemistry
-
Epithelium / metabolism
-
Epithelium / pathology
-
Gastrointestinal Tract / chemistry*
-
Gastrointestinal Tract / metabolism
-
Gastrointestinal Tract / pathology
-
Gene Expression Regulation, Neoplastic
-
Humans
-
Stomach Neoplasms / genetics
-
Stomach Neoplasms / pathology*
-
Tissue Distribution
-
Trefoil Factor-1
-
Tumor Suppressor Proteins / physiology*
-
Xenograft Model Antitumor Assays
Substances
-
Carrier Proteins
-
GKN2 protein, human
-
TFF1 protein, human
-
Trefoil Factor-1
-
Tumor Suppressor Proteins