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Infect Dis Obstet Gynecol. 2011;2011:319460. doi: 10.1155/2011/319460. Epub 2011 Aug 16.

Bacterial vaginosis and the natural history of human papillomavirus.

Author information

  • 1Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, NCCDPHP, DRH, 4770 Buford Highway, Mailstop K-34, Atlanta, GA 30341, USA. ccking@cdc.gov

Abstract

OBJECTIVE:

To evaluate associations between common vaginal infections and human papillomavirus (HPV).

STUDY DESIGN:

Data from up to 15 visits on 756 HIV-infected women and 380 high-risk HIV-uninfected women enrolled in the HIV Epidemiology Research Study (HERS) were evaluated for associations of bacterial vaginosis, trichomoniasis, and vaginal Candida colonization with prevalent HPV, incident HPV, and clearance of HPV in multivariate analysis.

RESULTS:

Bacterial vaginosis (BV) was associated with increased odds for prevalent (aOR = 1.14, 95% CI: 1.04, 1.26) and incident (aOR = 1.24, 95% CI: 1.04, 1.47) HPV and with delayed clearance of infection (aHR = 0.84, 95% CI: 0.72, 0.97). Whereas BV at the preceding or current visit was associated with incident HPV, in an alternate model for the outcome of incident BV, HPV at the current, but not preceding, visit was associated with incident BV.

CONCLUSION:

These findings underscore the importance of prevention and successful treatment of bacterial vaginosis.

PMID:
21869857
[PubMed - indexed for MEDLINE]
PMCID:
PMC3159014
Free PMC Article
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