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J Clin Invest. 2011 Sep;121(9):3395-7. doi: 10.1172/JCI58899. Epub 2011 Aug 25.

Finally! A human pancreatic β cell line.

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  • 1Section on Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA. gordon.weir@joslin.harvard.edu

Abstract

For decades, investigators have made numerous attempts to generate human pancreatic β cell lines that could be used to advance β cell biology, facilitate drug discovery, and provide a pathway to β cell replacement therapy for the treatment of diabetes. In this issue of the JCI, Ravassard and colleagues report that this has finally been achieved successfully with a multistep process that led to the generation of cells, which they termed EndoC-βH1 cells, that secreted insulin in response to glucose challenge.

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PMID:
21865653
[PubMed - indexed for MEDLINE]
PMCID:
PMC3163975
Free PMC Article

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