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J Clin Invest. 2011 Sep;121(9):3384-6. doi: 10.1172/JCI58297. Epub 2011 Aug 25.

Uroguanylin: how the gut got another satiety hormone.

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  • 1Metabolic Diseases Institute, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio 45237, USA.


Prouroguanylin is a gastrointestinal paracrine signal and prohormone that is secreted after nutrient ingestion. In this issue of the JCI, Valentino et al. show that prouroguanylin is converted to uroguanylin in the CNS, which can activate guanylyl cyclase 2C (GUCY2C) receptors in the brain to reduce food intake in mice. This 16-amino acid residue peptide is a novel component of the gut-brain axis that represents a new and unique opportunity to manipulate gut-brain signaling for therapeutic intervention in obesity.

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