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    Eur Neuropsychopharmacol. 2012 Apr;22(4):267-80. doi: 10.1016/j.euroneuro.2011.07.014. Epub 2011 Aug 24.

    Efficacy of a targeted cognitive-behavioral treatment program for cannabis use disorders (CANDIS).

    Source

    Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Chemnitzer Strasse 46,D-01187 Dresden, Germany.

    Abstract

    AIMS:

    To examine the efficacy, 3- and 6-month follow-up effects of a psychological treatment for older adolescents and adults with DSM-IV cannabis use disorders. The program was tailored to the needs of this patient population.

    EXPERIMENTAL PROCEDURES:

    A randomized controlled clinical trial of 122 patients aged 16 to 44 years with DSM-IV cannabis dependence as the main substance use diagnosis was conducted. Patients were randomly assigned to either Active Treatment (AT, n = 90) or a Delayed Treatment Control group (DTC, n = 32). Treatment consisted of 10 sessions of therapy, detailed in a strictly enforced manual. Assessments were conducted at baseline, during each therapy session, at post treatment and at follow-up assessments at 3 and 6 months.

    RESULTS:

    The treatment retention rate was 88%. Abstinence was achieved in 49% of AT patients and in 13% of those in DTC (p < 0.001; intend-to-treat (ITT) analysis). Further, AT patients improved significantly (p < = 0.001) in the frequency of cannabis use per week, addiction severity, number of disability days, and overall level of psychopathology. Program effects were maintained over a 3-month- (abstinence rate: 51%) and 6-month follow-up (45%) period.

    CONCLUSION:

    The treatment program is effective in obtaining abstinence as well as reducing cannabis use and improves the associated social and mental health burden.

    Copyright © 2011 Elsevier B.V. and ECNP. All rights reserved.

    PMID:
    21865014
    [PubMed - indexed for MEDLINE]

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