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Vaccine. 2011 Oct 19;29(45):7920-4. doi: 10.1016/j.vaccine.2011.08.073. Epub 2011 Aug 22.

Reactogenicity of two 2010 trivalent inactivated influenza vaccine formulations in adults.

Author information

  • 1Illawarra Medical Centre, Ballajura, Western Australia, Australia. alan@illawarramedical.com.au

Abstract

OBJECTIVE:

To assess the reactogenicity of two 2010 trivalent inactivated influenza vaccine (TIV) formulations among adults, including the formulation associated with febrile convulsions among children in Australia.

DESIGN, SETTING AND PARTICIPANTS:

We retrospectively interviewed persons aged ≥18 years who received TIV between 11 March and 24 April 2010 at a large general practice in Perth. All 160 persons who received Influvac® (Solvay) and a random sample of 190 of 451 persons who received Fluvax® (CSL Biotherapies) were included in the assessment; 127 (79%) recipients of Influvac® and 156 (82%) of the Fluvax® recipients completed the interview.

MAIN OUTCOME MEASURES:

Patient demographics, the presence of underlying medical conditions, prior influenza vaccination history, self-reported onset of local and/or systemic symptoms within 72 h following receipt of 2010 TIV, and use of anti-fever/pain medication following TIV vaccination were examined.

RESULTS:

The mean age of the vaccinees was 54 years for both the Fluvax® and Influvac® brand cohorts and there was no significant difference between the cohorts with regard to gender or the presence of underlying medical conditions. In bivariate analyses, reported swelling (18% vs 7%, p=0.009), muscle pain (12% vs 3%, p=0.014) and use of anti-fever/pain medication after TIV vaccination (12% vs 2%, p=0.008) were each significantly more common for patients who received Fluvax® compared to those who received Influvac®. In multivariate analyses simultaneously controlling for age, gender, receipt of seasonal influenza vaccine prior to 2010 and receipt of 2009 H1N1 pandemic vaccine, vaccination with Fluvax® TIV was a significant independent predictor of muscle pain and/or swelling (OR=3.3, 95% CI 1.5-7.4 p=0.004). No significant differences in the proportion of patients reporting systemic reactions were observed.

CONCLUSIONS:

In this setting, 2010 Fluvax® was associated with a greater likelihood of local reactions among adults, compared to 2010 Influvac® TIV.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21864621
[PubMed - indexed for MEDLINE]
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