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J Biomed Sci. 2011 Aug 24;18:66. doi: 10.1186/1423-0127-18-66.

Roles of planar cell polarity pathways in the development of neural [correction of neutral] tube defects.

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  • 1Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

Abstract

Neural tube defects (NTDs) are the second most common birth defect in humans. Despite many advances in the understanding of NTDs and the identification of many genes related to NTDs, the fundamental etiology for the majority of cases of NTDs remains unclear. Planar cell polarity (PCP) signaling pathway, which is important for polarized cell movement (such as cell migration) and organ morphogenesis through the activation of cytoskeletal pathways, has been shown to play multiple roles during neural tube closure. The disrupted function of PCP pathway is connected with some NTDs. Here, we summarize our current understanding of how PCP factors affect the pathogenesis of NTDs.

PMID:
21864354
[PubMed - indexed for MEDLINE]
PMCID:
PMC3175158
Free PMC Article
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