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Curr Opin Chem Biol. 2011 Oct;15(5):657-63. doi: 10.1016/j.cbpa.2011.07.023. Epub 2011 Aug 20.

Inside the 40S ribosome assembly machinery.

Author information

  • Department of Cancer Biology, The Scripps Research Institute, Jupiter, FL 33458, USA. kkarbst@scripps.edu

Abstract

Ribosome assembly involves rRNA transcription, modification, folding and cleavage from precursor transcripts, and association of ribosomal proteins (Rps). In bacteria, this complex process requires only a handful of proteins in addition to those needed for rRNA transcription, modification and cleavage, while in eukaryotes a large machinery comprising ∼200 proteins in the yeast S. cerevisiae has been identified. Furthermore, while the bacterial assembly factors generally produce only cold-sensitive phenotypes upon deletion, most of the eukaryotic assembly factors are essential, comprising ∼20% of essential yeast proteins. This review explores recent rapid progress in the structural and functional dissection of the 40S assembly machinery.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21862385
[PubMed - indexed for MEDLINE]
PMCID:
PMC3329787
Free PMC Article

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