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Evodevo. 2011 Aug 24;2:17. doi: 10.1186/2041-9139-2-17.

A comparative gene expression database for invertebrates.

Author information

  • 1Kewalo Marine Laboratory, PBRC, University of Hawaii at Manoa, 41, Ahui Street, Honolulu, 96734, HI, USA. rottinge@hawaii.edu.

Abstract

BACKGROUND:

As whole genome and transcriptome sequencing gets cheaper and faster, a great number of 'exotic' animal models are emerging, rapidly adding valuable data to the ever-expanding Evo-Devo field. All these new organisms serve as a fantastic resource for the research community, but the sheer amount of data, some published, some not, makes detailed comparison of gene expression patterns very difficult to summarize - a problem sometimes even noticeable within a single lab. The need to merge existing data with new information in an organized manner that is publicly available to the research community is now more necessary than ever.

DESCRIPTION:

In order to offer a homogenous way of storing and handling gene expression patterns from a variety of organisms, we have developed the first web-based comparative gene expression database for invertebrates that allows species-specific as well as cross-species gene expression comparisons. The database can be queried by gene name, developmental stage and/or expression domains.

CONCLUSIONS:

This database provides a unique tool for the Evo-Devo research community that allows the retrieval, analysis and comparison of gene expression patterns within or among species. In addition, this database enables a quick identification of putative syn-expression groups that can be used to initiate, among other things, gene regulatory network (GRN) projects.

PMID:
21861937
[PubMed]
PMCID:
PMC3180427
Free PMC Article

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