Format

Send to:

Choose Destination
See comment in PubMed Commons below
Lipids Health Dis. 2011 Aug 23;10:149. doi: 10.1186/1476-511X-10-149.

Protective effect of quercetin against oxidative stress caused by dimethoate in human peripheral blood lymphocytes.

Author information

  • 1Unité de Biotechnologie et Pathologies, Institut Supérieur de Biotechnologie de Sfax, 3038 Tunisie. bochragargouri@yahoo.fr

Abstract

BACKGROUND:

The aim of this study is to investigate the effect of quercetin in alleviating the cytotoxic effects of Dimethoate in human peripheral blood lymphocytes.

METHODS:

Lymphocytes were divided into too groups. The first group, lymphocytes were incubated for 4 h at 37°C with different concentrations (0, 40, 60 and 100 mM) of Dimethoate. The second group was preincubated with quercetin for 30 min and followed by Dim incubation for 4 h at 37°C.

RESULTS:

Following in vitro incubation, Dimethoate caused a significant increase in malondialdehyde levels, a significant decrease in thiol levels, as well as a significant increase in superoxide dismutase, and catalase activities in lymphocytes at different concentrations. Quercetin pretreated lymphocytes showed a significant protection against the cytotoxic effects inducted by Dimethoate on the studied parameters.

CONCLUSION:

In conclusion, antioxidant quercetin could protect against Dimethoate-induced oxidative stress by decreasing lipid peroxidation, protein oxidation and increasing superoxide dismutase and catalase activities in human lymphocytes.

PMID:
21861917
[PubMed - indexed for MEDLINE]
PMCID:
PMC3179742
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Write to the Help Desk