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BMC Neurol. 2011 Aug 23;11:105. doi: 10.1186/1471-2377-11-105.

Metabolic changes in concussed American football players during the acute and chronic post-injury phases.

Author information

  • 1Centre de Recherche en Neuropsychologie et Cognition, Department of Psychology, University of Montreal, Montréal, Québec, Canada. luke.henry@umontreal.ca

Abstract

BACKGROUND:

Despite negative neuroimaging findings many athletes display neurophysiological alterations and post-concussion symptoms that may be attributable to neurometabolic alterations.

METHODS:

The present study investigated the effects of sports concussion on brain metabolism using 1H-MR Spectroscopy by comparing a group of 10 non-concussed athletes with a group of 10 concussed athletes of the same age (mean: 22.5 years) and education (mean: 16 years) within both the acute and chronic post-injury phases. All athletes were scanned 1-6 days post-concussion and again 6-months later in a 3T Siemens MRI.

RESULTS:

Concussed athletes demonstrated neurometabolic impairment in prefrontal and motor (M1) cortices in the acute phase where NAA:Cr levels remained depressed relative to controls. There was some recovery observed in the chronic phase where Glu:Cr levels returned to those of control athletes; however, there was a pathological increase of m-I:Cr levels in M1 that was only present in the chronic phase.

CONCLUSIONS:

These results confirm cortical neurometabolic changes in the acute post-concussion phase as well as recovery and continued metabolic abnormalities in the chronic phase. The results indicate that complex pathophysiological processes differ depending on the post-injury phase and the neurometabolite in question.

PMID:
21861906
[PubMed - indexed for MEDLINE]
PMCID:
PMC3176163
Free PMC Article

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