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Nat Rev Mol Cell Biol. 2011 Aug 23;12(9):551-64. doi: 10.1038/nrm3176.

Molecular control of endothelial cell behaviour during blood vessel morphogenesis.

Author information

  • 1Department of Biochemistry and Biophysics, Program in Developmental Biology, Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA. S.P.Herbert@leeds.ac.uk

Abstract

The vertebrate vasculature forms an extensive branched network of blood vessels that supplies tissues with nutrients and oxygen. During vascular development, coordinated control of endothelial cell behaviour at the levels of cell migration, proliferation, polarity, differentiation and cell-cell communication is critical for functional blood vessel morphogenesis. Recent data uncover elaborate transcriptional, post-transcriptional and post-translational mechanisms that fine-tune key signalling pathways (such as the vascular endothelial growth factor and Notch pathways) to control endothelial cell behaviour during blood vessel sprouting (angiogenesis). These emerging frameworks controlling angiogenesis provide unique insights into fundamental biological processes common to other systems, such as tissue branching morphogenesis, mechanotransduction and tubulogenesis.

PMID:
21860391
[PubMed - indexed for MEDLINE]
PMCID:
PMC3319719
Free PMC Article

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