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J Occup Environ Med. 2011 Sep;53(9):1078-86. doi: 10.1097/JOM.0b013e318229a938.

Association of general fatigue with cellular immune indicators among healthy white-collar employees.

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  • 1Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 45226, USA. nakataatky@umin.ac.jp

Abstract

OBJECTIVE:

Although fatigue is a common complaint in the working population, underlying immunological mechanisms are not well understood. This study investigated the association of general fatigue with cellular immune indicators.

METHODS:

A total of 148 healthy white-collar employees (70% men) underwent a blood draw for the measurement of natural killer (NK), B, and T cell counts as well as NK cell cytotoxicity (NKCC) and completed two different fatigue scales, that is, Profile of Mood State (POMS) and Maastricht Questionnaire (MQ).

RESULTS:

Multiple linear regression analyses revealed that POMS fatigue score was significantly associated with decreases of NK cells (β = -.407) and NKCC (β = -.215), whereas MQ fatigue score was significantly associated with reduced NK cells (β = -.290) but not with NKCC (β = -.127).

CONCLUSION:

The results suggest that general fatigue may be related to impaired NK cell competency among healthy employees.

(C)2011The American College of Occupational and Environmental Medicine

[PubMed - indexed for MEDLINE]
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