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Skin Pharmacol Physiol. 2012;25(1):17-24. doi: 10.1159/000330489. Epub 2011 Aug 22.

Application of dermal microdialysis for the determination of bioavailability of clobetasol propionate applied to the skin of human subjects.

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  • 1Rhodes University, Grahamstown, South Africa.

Abstract

Dermal microdialysis was used to assess the bioavailability of a topical corticosteroid, clobetasol propionate, following application onto the skin of human subjects. The penetration of clobetasol propionate from a 4% m/v ethanolic solution applied onto 4 sites on one forearm of healthy human volunteers was studied. A lipid emulsion, IntralipidĀ®, was used as the perfusate and linear microdialysis probes with a 2-kDa cutoff were inserted intradermally at the designated sites. The results indicated that Intralipid could be used as a suitable perfusate for in vivo microdialysis of this lipophilic drug of interest. Furthermore, the study clearly demonstrated the application of dermal microdialysis as a valuable tool to assess the bioavailability/bioequivalence of clobetasol propionate penetration into the skin following topical application.

Copyright Ā© 2011 S. Karger AG, Basel.

PMID:
21860254
[PubMed - indexed for MEDLINE]
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