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FEBS Lett. 2011 Oct 3;585(19):3006-10. doi: 10.1016/j.febslet.2011.08.016. Epub 2011 Aug 16.

Free sphingobases induce RBOHD-dependent reactive oxygen species production in Arabidopsis leaves.

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  • 1Julius-von-Sachs Institute of Biosciences, Pharmaceutical Biology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.

Abstract

Sphingolipids are implied in several regulatory processes, including cell death. Levels of the free sphingobase t18:0 (phytosphingosine) increase in Arabidopsis in response to the bacterial pathogen Pseudomonas syringae. To gain information on sphingobase-induced signaling, we determined kinetics of leaf reactive oxygen species (ROS) levels and cell death in response to specific sphingobases. t18:0, d18:0 and d17:1, but not d20:0, induced ROS and cell death within 1.5-2h. Early sphingobase-induced ROS production was independent of cell death induction and required the NADPH oxidase Respiratory Burst Oxidase Homolog D (RBOHD). Specific sphingobases can therefore induce cell death and require RBOHD for early ROS induction in plants.

Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

PMID:
21856300
[PubMed - indexed for MEDLINE]
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