Schizophr Bull. 1990;16(1):97-110.

Dopaminergic mechanisms in idiopathic and drug-induced psychoses.

Source

Hillside Hospital, Glen Oaks, NY 11004.

Abstract

Stimulant drugs such as cocaine and amphetamine are among the most commonly abused substances by schizophrenic patients. This may be due in part to aspects of the illness and treatment side effects that impel patients to use dopamine agonist drugs. Dopaminergic neural systems have been shown to mediate both stimulant drug effects and schizophrenia. Because of the hypothesized overlap in the pathophysiology of schizophrenia and the neurobiological effects of chronic stimulant use, the potential for serious complication of the primary disease by substance abuse exists. This article reviews the neurobiological mechanisms of behavioral sensitization and neurotoxicity associated with chronic stimulant administration in the context of pathophysiological theories of schizophrenia. Discussion focuses on the potential impact of stimulant use on the disease process as well as the manifest phenomenology and course of schizophrenia.

PMID:: 2185538; [PubMed - indexed for MEDLINE]

Free full text

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Drug Abuse - MedlinePlus Health Information

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Review Stimulant-induced psychosis, the dopamine theory of schizophrenia, and the habenula. [Brain Res Brain Res Rev. 1994]
Review Stimulant-induced psychosis, the dopamine theory of schizophrenia, and the habenula.
Ellison G. Brain Res Brain Res Rev. 1994 May; 19(2):223-39.
[Clinical aspects and follow-up of dopamine-induced psychoses in continuous dopaminergic therapy and their implications for the dopamine hypothesis of schizophrenic symptoms]. [Nervenarzt. 1995]
[Clinical aspects and follow-up of dopamine-induced psychoses in continuous dopaminergic therapy and their implications for the dopamine hypothesis of schizophrenic symptoms].
Heinz A, Przuntek H, Winterer G, Pietzcker A. Nervenarzt. 1995 Sep; 66(9):662-9.
Review Neurobiological basis of relapse prediction in stimulant-induced psychosis and schizophrenia: the role of sensitization. [Mol Psychiatry. 1999]
Review Neurobiological basis of relapse prediction in stimulant-induced psychosis and schizophrenia: the role of sensitization.
Yui K, Goto K, Ikemoto S, Ishiguro T, Angrist B, Duncan GE, Sheitman BB, Lieberman JA, Bracha SH, Ali SF. Mol Psychiatry. 1999 Nov; 4(6):512-23.
Review Role of oxytocin in the neuroadaptation to drugs of abuse. [Psychoneuroendocrinology. 1994]
Review Role of oxytocin in the neuroadaptation to drugs of abuse.
Sarnyai Z, Kovács GL. Psychoneuroendocrinology. 1994; 19(1):85-117.
Influence of compulsivity of drug abuse on dopaminergic modulation of attentional bias in stimulant dependence. [Arch Gen Psychiatry. 2010]
Influence of compulsivity of drug abuse on dopaminergic modulation of attentional bias in stimulant dependence.
Ersche KD, Bullmore ET, Craig KJ, Shabbir SS, Abbott S, Müller U, Ooi C, Suckling J, Barnes A, Sahakian BJ, et al. Arch Gen Psychiatry. 2010 Jun; 67(6):632-44.

See reviews... See all...

Cited by 12 PubMed Central articles

Dopamine in the history of the schizophrenic brain: recent contributions of brain-imaging studies. [Dialogues Clin Neurosci. 2000]
Dopamine in the history of the schizophrenic brain: recent contributions of brain-imaging studies.
Lamelle M, Abi-Dargham A. Dialogues Clin Neurosci. 2000 Dec; 2(4):359-72.
Drug-induced psychosis: how to avoid star gazing in schizophrenia research by looking at more obvious sources of light. [Front Behav Neurosci. 2011]
Drug-induced psychosis: how to avoid star gazing in schizophrenia research by looking at more obvious sources of light.
Paparelli A, Di Forti M, Morrison PD, Murray RM. Front Behav Neurosci. 2011 Jan 17; 5:1. Epub 2011 Jan 17.
Gestational methylazoxymethanol acetate administration: a developmental disruption model of schizophrenia. [Behav Brain Res. 2009]
Gestational methylazoxymethanol acetate administration: a developmental disruption model of schizophrenia.
Lodge DJ, Grace AA. Behav Brain Res. 2009 Dec 7; 204(2):306-12. Epub 2009 Feb 2.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Dopaminergic mechanisms in idiopathic and drug-induced psychoses.
Dopaminergic mechanisms in idiopathic and drug-induced psychoses.
Schizophr Bull. 1990 ;16(1):97-110.

PubMed
What is the best treatment for primary infected aortic aneurysms?
What is the best treatment for primary infected aortic aneurysms?
Eur J Vasc Endovasc Surg. 2011 Nov ;42(5):625-6. Epub 2011 Aug 19 .

PubMed
Impact of substance abuse on the course and outcome of schizophrenia.
Impact of substance abuse on the course and outcome of schizophrenia.
Schizophr Bull. 1990 ;16(1):87-95.

PubMed
A population-based study of the prevalence and sociodemographic risk factors of ...
A population-based study of the prevalence and sociodemographic risk factors of self-reported epilepsy among adults in the United Kingdom.
Seizure. 2011 Dec ;20(10):784-8. Epub 2011 Aug 19 .

PubMed
Acute effects of drug abuse in schizophrenic patients: clinical observations and...
Acute effects of drug abuse in schizophrenic patients: clinical observations and patients' self-reports.
Schizophr Bull. 1990 ;16(1):69-79.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Dopaminergic mechanisms in idiopathic and drug-induced psychoses.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 12 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information