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    Trans R Soc Trop Med Hyg. 2011 Nov;105(11):667-9. Epub 2011 Aug 19.

    High prevalence of toxinogenic Clostridium difficile in Nigerian adult HIV patients.

    Onwueme K, Fadairo Y, Idoko L, Onuh J, Alao O, Agaba P, Lawson L, Ukomadu C, Idoko J.

    Source

    Brigham and Women's Hospital, Boston, MA, USA. kenolisa@obalafoundation.org

    Abstract

    Clostridium difficile is the most commonly identified bacterial cause of nosocomial and HIV-related diarrhea. In many developing countries, antibiotic access is unregulated. Nigeria has the third highest HIV burden worldwide. Due to perceptions of low prevalence and resource incapacity, patients with diarrhea are not tested for toxinogenic C. difficile infection (CDI). In this pilot study which included 97 HIV-positive patients at two hospitals in Nigeria, the estimated prevalence of CDI was 43% and 14% for in-patients and out-patients respectively. HIV-positive out-patients were more likely to have toxinogenic CDI than non-HIV out-patients (P=0.007, Fisher's exact test).

    Copyright © 2011 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

    PMID:
    21855100
    [PubMed - indexed for MEDLINE]

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