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Cell. 2011 Aug 19;146(4):510-8. doi: 10.1016/j.cell.2011.07.013.

Mechanisms for the inheritance of chromatin states.

Author information

  • Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. danesh@hms.harvard.edu

Abstract

Studies in eukaryotes ranging from yeast to mammals indicate that specific chromatin structures can be inherited following DNA replication via mechanisms acting in cis. Both the initial establishment of such chromatin structures and their inheritance require sequence-dependent specificity factors and changes in histone posttranslational modifications. Here I propose models for the maintenance of epigenetic information in which DNA silencers or nascent RNA scaffolds act as sensors that work cooperatively with parentally inherited histones to re-establish chromatin states following DNA replication.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
21854979
[PubMed - indexed for MEDLINE]
PMCID:
PMC3244757
Free PMC Article
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