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Cell. 2011 Aug 19;146(4):501-3. doi: 10.1016/j.cell.2011.08.003.

Elongated membrane zones boost interactions of diffusing proteins.

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  • 1Program in Physical Biology, Eunice Kennedy Schriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.


Biological membranes are two dimensional, making the discovery of quasi-one-dimensional diffusion of membrane proteins puzzling. Jaqaman et al. (2011) now show that actomyosin and tubulin interact to establish long, thin diffusion corridors, thereby increasing the effective concentration of select membrane proteins to promote their interactions and modulate signaling.

Copyright © 2011 Elsevier Inc. All rights reserved.

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