Diffusion of small molecules inside a peptide hydrogel

Chem Commun (Camb). 2011 Oct 7;47(37):10455-7. doi: 10.1039/c1cc13943f. Epub 2011 Aug 19.

Abstract

A set of four phenylalanine analogues experiences diffusion retardation when transferred from phosphate-buffered saline into a peptide hydrogel of the same pH and ionic strength. The extent of retardation increases linearly with logP(oct), their lipophilicity.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Amino Acid Sequence
  • Diffusion
  • Hydrogels / chemistry*
  • Hydrophobic and Hydrophilic Interactions
  • Oligopeptides / chemistry*
  • Phenylalanine / chemistry*

Substances

  • Hydrogels
  • Oligopeptides
  • Phenylalanine