Format

Send to:

Choose Destination
See comment in PubMed Commons below
Pediatr Infect Dis J. 2011 Sep;30(9):804-6. doi: 10.1097/INF.0b013e3182186035.

Linezolid and lactic acidosis: a role for lactate monitoring with long-term linezolid use in children.

Author information

  • 1Department of Pediatric Critical Care Medicine, Division of Infectious Disease, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA. suer4@upmc.edu

Abstract

Linezolid administration has been associated with lactic acidosis in adults; however, the same phenomenon has not been reported in children. Mitochondrial protein synthesis inhibition is a demonstrated mechanism for toxicity, which therefore may manifest as lactic acidosis. Three cases of linezolid-associated lactic acidosis in children are reported to reinforce the need for pediatric caregivers to be vigilant of this potential side effect.

PMID:
21852764
[PubMed - indexed for MEDLINE]
PMCID:
PMC3158859
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Lippincott Williams & Wilkins Icon for PubMed Central
    Loading ...
    Write to the Help Desk