Annu Rev Med. 1990;41:99-115.

Insulin receptor structure and function in normal and pathological conditions.

Source

Department of Pharmacology, Stanford University Medical Center, California 94305.

Abstract

The insulin receptor is a large cell surface glycoprotein that concentrates insulin at the site of action and also initiates responses to insulin. The receptor is a disulfide-linked oligomer comprised of two alpha and two beta subunits. Signal transduction through the insulin receptor appears to require the activation of an intrinsic tyrosine-specific protein kinase activity. A variety of disorders, both acquired and genetic, are associated with the development of insulin resistance and are frequently the result of cellular defects in insulin receptor structure, function, and action. The recent cloning of several mutant receptors from patients with genetic forms of extreme insulin resistance has increased our understanding of insulin resistance on the molecular level.

PMID:: 2184752; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Receptor, Insulin

Grant Support

DK 34926/DK/NIDDK NIH HHS/United States

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Review The nature and regulation of the insulin receptor: structure and function. [Annu Rev Physiol. 1985]
Review The nature and regulation of the insulin receptor: structure and function.
Czech MP. Annu Rev Physiol. 1985; 47:357-81.
Review Insulin receptors: structure and function. [Experientia. 1986]
Review Insulin receptors: structure and function.
Van Obberghen E, Gammeltoft S. Experientia. 1986 Jul 15; 42(7):727-34.
Review Insulin receptors: structure and function. [Experientia Suppl. 1987]
Review Insulin receptors: structure and function.
Van Obberghen E, Gammeltoft S. Experientia Suppl. 1987; 53:31-45.
Review Protein kinase activity of the insulin receptor. [Biochem J. 1986]
Review Protein kinase activity of the insulin receptor.
Gammeltoft S, Van Obberghen E. Biochem J. 1986 Apr 1; 235(1):1-11.
Tyrosine kinase activity of the insulin receptor of patients with type A extreme insulin resistance: studies with circulating mononuclear cells and cultured lymphocytes. [J Clin Endocrinol Metab. 1984]
Tyrosine kinase activity of the insulin receptor of patients with type A extreme insulin resistance: studies with circulating mononuclear cells and cultured lymphocytes.
Grunberger G, Comi RJ, Taylor SI, Gorden P. J Clin Endocrinol Metab. 1984 Dec; 59(6):1152-8.

See reviews... See all...

Cited by 3 PubMed Central articles

Review Thiazolidinediones: effects on insulin resistance and the cardiovascular system. [Br J Pharmacol. 2008]
Review Thiazolidinediones: effects on insulin resistance and the cardiovascular system.
Quinn CE, Hamilton PK, Lockhart CJ, McVeigh GE. Br J Pharmacol. 2008 Feb; 153(4):636-45. Epub 2007 Oct 1.
Elevated protein tyrosine phosphatase activity and increased membrane viscosity are associated with impaired activation of the insulin receptor kinase in old rats. [Biochem J. 1994]
Elevated protein tyrosine phosphatase activity and increased membrane viscosity are associated with impaired activation of the insulin receptor kinase in old rats.
Nadiv O, Shinitzky M, Manu H, Hecht D, Roberts CT Jr, LeRoith D, Zick Y. Biochem J. 1994 Mar 1; 298 ( Pt 2):443-50.
A complex of GRB2-dynamin binds to tyrosine-phosphorylated insulin receptor substrate-1 after insulin treatment. [EMBO J. 1994]
A complex of GRB2-dynamin binds to tyrosine-phosphorylated insulin receptor substrate-1 after insulin treatment.
Ando A, Yonezawa K, Gout I, Nakata T, Ueda H, Hara K, Kitamura Y, Noda Y, Takenawa T, Hirokawa N. EMBO J. 1994 Jul 1; 13(13):3033-8.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Insulin receptor structure and function in normal and pathological conditions.
Insulin receptor structure and function in normal and pathological conditions.
Annu Rev Med. 1990 ;41:99-115.

PubMed
Exposure assessment for methyl and total mercury from seafood consumption in Kor...
Exposure assessment for methyl and total mercury from seafood consumption in Korea, 2005 to 2008.
J Environ Monit. 2011 Sep ;13(9):2400-5. Epub 2011 Aug 16 .

PubMed
Porphyria and porphyrin metabolism.
Porphyria and porphyrin metabolism.
Annu Rev Med. 1990 ;41:457-69.

PubMed
Use of the NHS Choices website for primary care consultations: results from onli...
Use of the NHS Choices website for primary care consultations: results from online and general practice surveys.
JRSM Short Rep. 2011 Jul ;2(7):56. Epub 2011 Jul 7 .

PubMed
Adherence to the Mediterranean diet and quality of life in the SUN Project.
Adherence to the Mediterranean diet and quality of life in the SUN Project.
Eur J Clin Nutr. 2012 Mar ;66(3):360-8. doi: 10.1038/ejcn.2011.146. Epub 2011 Aug 17 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: