Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression.
Severus E, Seemuller F, Berger M, Dittmann S, Obermeier M, Pfennig A, Riedel M, Frangou S, Moller HJ, Bauer M. BMC Med. 2012 Jul 2; 10(1):67. Epub 2012 Jul 2.