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Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14163-8. doi: 10.1073/pnas.1111241108. Epub 2011 Aug 15.

Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects.

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  • 1Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA.

Abstract

Mir-290 through mir-295 (mir-290-295) is a mammalian-specific microRNA (miRNA) cluster that, in mice, is expressed specifically in early embryos and embryonic germ cells. Here, we show that mir-290-295 plays important roles in embryonic development as indicated by the partially penetrant lethality of mutant embryos. In addition, we show that in surviving mir-290-295-deficient embryos, female but not male fertility is compromised. This impairment in fertility arises from a defect in migrating primordial germ cells and occurs equally in male and female mutant animals. Male mir-290-295(-/-) mice, due to the extended proliferative lifespan of their germ cells, are able to recover from this initial germ cell loss and are fertile. Female mir-290-295(-/-) mice are unable to recover and are sterile, due to premature ovarian failure.

PMID:
21844366
[PubMed - indexed for MEDLINE]
PMCID:
PMC3161528
Free PMC Article
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