Enantioselective hydroformylation of aniline derivatives

J Org Chem. 2011 Sep 16;76(18):7590-6. doi: 10.1021/jo201328d. Epub 2011 Aug 15.

Abstract

We have developed a ligand that reversibly binds to aniline substrates, allowing for the control of regioselectivity and enantioselectivity in hydroformylation. In this paper we address how the electronics of the aniline ring affect both the binding of the substrate to the ligand and the enantioselectivity in this reaction.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aniline Compounds / chemistry*
  • Formates / chemistry*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Stereoisomerism

Substances

  • Aniline Compounds
  • Formates
  • formic acid
  • aniline