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    Results: 2

    1.

    Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation.

    Wang F, Chan CH, Chen K, Guan X, Lin HK, Tong Q.

    Oncogene. 2012 Mar 22;31(12):1546-57. doi: 10.1038/onc.2011.347. Epub 2011 Aug 15.

    PMID:
    21841822
    [PubMed - indexed for MEDLINE]
    2.

    MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation.

    Fu W, Ma Q, Chen L, Li P, Zhang M, Ramamoorthy S, Nawaz Z, Shimojima T, Wang H, Yang Y, Shen Z, Zhang Y, Zhang X, Nicosia SV, Zhang Y, Pledger JW, Chen J, Bai W.

    J Biol Chem. 2009 May 22;284(21):13987-4000. Epub 2009 Mar 25.

    PMID:
    19321440
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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