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Ceska Gynekol. 2011 Jun;76(3):216-21.

[Risk-reducing surgery in women at hereditary risk of gynaecological cancer].

[Article in Czech]

Author information

  • Onkogynekologické centrum, Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha. michal.zikan@lf1.cuni.cz

Abstract

OBJECTIVE:

To present up-to-date knowledge concerning risk-reducing surgery in carriers of susceptibility mutations among hereditary breast/ovarian cancer syndrome and Lynch syndrome.

SUBJECT:

Review.

SETTING:

Oncogynecological Center, Department of Obstetrics and Gynecology, Charles University in Prague - First Faculty of Medicine and General Faculty Hospital, Prague.

SUBJECT AND METHOD:

After having reviewed the now-a-days literature and summarized our experience we present here an overview of risk-reducing strategies in gynecology and a proposal of guidelines to risk-reducing salpingo-oophorectomy and hysterectomy.

CONCLUSION:

Risk-reducing salpingo-oophorectomy or hysterectomy is the most effective strategy for gynecological cancer prevention in susceptibility gene mutation carriers so far. This type of surgery, however, requires specific indication work-up and techniques different from those standardly used.

PMID:
21838153
[PubMed - indexed for MEDLINE]
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