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J Clin Microbiol. 2011 Oct;49(10):3667-8. doi: 10.1128/JCM.00650-11. Epub 2011 Aug 10.

Evaluation of pooling strategies for acute HIV-1 infection screening using nucleic acid amplification testing.

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  • 1Wadsworth Center, New York State Department of Health, Albany, NY 12201-2002, USA.

Abstract

A 128-member specimen pooling scheme for acute HIV infection (AHI) detection was evaluated using 21 AHI specimens (range, 1,520 to 500,000 copies/ml) previously identified by RNA testing of 16-member plasma pools. HIV-1 RNA was detectable in 128-member pools for all 21 specimens; however, one pool created from a specimen with 1,827 copies/ml was nonreactive in one of three replicates.

PMID:
21832020
[PubMed - indexed for MEDLINE]
PMCID:
PMC3187297
Free PMC Article
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