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Trends Microbiol. 2011 Oct;19(10):492-500. doi: 10.1016/j.tim.2011.07.002. Epub 2011 Aug 9.

A role for systems epidemiology in tuberculosis research.

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  • 1Division of Mycobacterial Research, MRC National Institute for Medical Research, London, UK.

Abstract

Despite being a curable disease, tuberculosis (TB) killed more people in 2009 than during any previous year in history. Progress in TB research has been slow, and remains burdened by important gaps in our knowledge of the basic biology of Mycobacterium tuberculosis, the causative agent of TB, and its interaction with the human host. Fortunately, major systems biology initiatives have recently been launched that will help fill some of these gaps. However, to fully comprehend TB and control this disease globally, current systems biological approaches will not suffice. The influence of host and pathogen diversity, changes in human demography, and socioeconomic and environmental factors will also need to be considered. Such a multidisciplinary approach might be best described as 'systems epidemiology' in an effort to overcome the traditional boundaries between basic biology and classical epidemiology.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21831640
[PubMed - indexed for MEDLINE]
PMCID:
PMC3184389
Free PMC Article

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