Mol Cell Biol. 1990 May;10(5):2104-10.

Positive control of sporulation-specific genes by the IME1 and IME2 products in Saccharomyces cerevisiae.

Source

Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032.

Abstract

In the yeast Saccharomyces cerevisiae, meiosis and spore formation require the induction of sporulation-specific genes. Two genes are thought to activate the sporulation program: IME1 and IME2 (inducer of meiosis). Both genes are induced upon entry into meiosis, and IME1 is required for IME2 expression. We report here that IME1 is essential for expression of four sporulation-specific genes. In contrast, IME2 is not absolutely essential for expression of the sporulation-specific genes, but contributes to their rapid induction. Expression of IME2 from a heterologous promoter permits the expression of these sporulation-specific genes, meiotic recombination, and spore formation in the absence of IME1. We propose that the IME1 and IME2 products can each activate sporulation-specific genes independently. In addition, the IME1 product stimulates sporulation-specific gene expression indirectly through activation of IME2 expression.

PMID:: 2183020; [PubMed - indexed for MEDLINE]
PMCID:: PMC360558

Free PMC Article

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

GM3951/GM/NIGMS NIH HHS/United States

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Molecular Biology Databases

Saccharomyces Genome Database

Supplemental Content

Save items

Related citations in PubMed

Role of IME1 expression in regulation of meiosis in Saccharomyces cerevisiae. [Mol Cell Biol. 1990]
Role of IME1 expression in regulation of meiosis in Saccharomyces cerevisiae.
Smith HE, Su SS, Neigeborn L, Driscoll SE, Mitchell AP. Mol Cell Biol. 1990 Dec; 10(12):6103-13.
A transcriptional cascade governs entry into meiosis in Saccharomyces cerevisiae. [Mol Cell Biol. 1989]
A transcriptional cascade governs entry into meiosis in Saccharomyces cerevisiae.
Smith HE, Mitchell AP. Mol Cell Biol. 1989 May; 9(5):2142-52.
Identification of functionally related genes that stimulate early meiotic gene expression in yeast. [Genetics. 1993]
Identification of functionally related genes that stimulate early meiotic gene expression in yeast.
Su SS, Mitchell AP. Genetics. 1993 Jan; 133(1):67-77.
Review Control of meiotic gene expression in Saccharomyces cerevisiae. [Microbiol Rev. 1994]
Review Control of meiotic gene expression in Saccharomyces cerevisiae.
Mitchell AP. Microbiol Rev. 1994 Mar; 58(1):56-70.
Review Transcriptional regulation of meiosis in budding yeast. [Int Rev Cytol. 2003]
Review Transcriptional regulation of meiosis in budding yeast.
Kassir Y, Adir N, Boger-Nadjar E, Raviv NG, Rubin-Bejerano I, Sagee S, Shenhar G. Int Rev Cytol. 2003; 224:111-71.

See reviews... See all...

Cited by 56 PubMed Central articles

Yeast IME2 functions early in meiosis upstream of cell cycle-regulated SBF and MBF targets. [PLoS One. 2012]
Yeast IME2 functions early in meiosis upstream of cell cycle-regulated SBF and MBF targets.
Brush GS, Najor NA, Dombkowski AA, Cukovic D, Sawarynski KE. PLoS One. 2012; 7(2):e31575. Epub 2012 Feb 29.
Review Regulation of entry into gametogenesis. [Philos Trans R Soc Lond B Biol...]
Review Regulation of entry into gametogenesis.
van Werven FJ, Amon A. Philos Trans R Soc Lond B Biol Sci. 2011 Dec 27; 366(1584):3521-31.
Regulated antisense transcription controls expression of cell-type-specific genes in yeast. [Mol Cell Biol. 2011]
Regulated antisense transcription controls expression of cell-type-specific genes in yeast.
Gelfand B, Mead J, Bruning A, Apostolopoulos N, Tadigotla V, Nagaraj V, Sengupta AM, Vershon AK. Mol Cell Biol. 2011 Apr; 31(8):1701-9. Epub 2011 Feb 7.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Positive control of sporulation-specific genes by the IME1 and IME2 products in ...
Positive control of sporulation-specific genes by the IME1 and IME2 products in Saccharomyces cerevisiae.
Mol Cell Biol. 1990 May ;10(5):2104-10.

PubMed
Structure of micelle-bound adrenomedullin: a first step toward the analysis of i...
Structure of micelle-bound adrenomedullin: a first step toward the analysis of its interactions with receptors and small molecules.
Biopolymers. 2012 Jan ;97(1):45-53. doi: 10.1002/bip.21700. Epub 2011 Aug 9 .

PubMed
Aurora-A interacts with AP-2α and down regulates its transcription activity.
Aurora-A interacts with AP-2α and down regulates its transcription activity.
PLoS One. 2011 ;6(8):e23110. Epub 2011 Aug 1 .

PubMed
Cost-effectiveness of 2009 pandemic influenza A(H1N1) vaccination in the United ...
Cost-effectiveness of 2009 pandemic influenza A(H1N1) vaccination in the United States.
PLoS One. 2011 ;6(7):e22308. Epub 2011 Jul 29 .

PubMed
Fine mapping of five loci associated with low-density lipoprotein cholesterol de...
Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability.
PLoS Genet. 2011 Jul ;7(7):e1002198. Epub 2011 Jul 28 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: