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PLoS One. 2011;6(7):e22964. doi: 10.1371/journal.pone.0022964. Epub 2011 Jul 29.

Task-induced deactivation from rest extends beyond the default mode brain network.

Author information

  • 1Institut d'Alta Tecnologia-PRBB, CRC Mar, Hospital del Mar, Barcelona, Spain. habj@unimelb.edu.au

Abstract

Activity decreases, or deactivations, of midline and parietal cortical brain regions are routinely observed in human functional neuroimaging studies that compare periods of task-based cognitive performance with passive states, such as rest. It is now widely held that such task-induced deactivations index a highly organized 'default-mode network' (DMN): a large-scale brain system whose discovery has had broad implications in the study of human brain function and behavior. In this work, we show that common task-induced deactivations from rest also occur outside of the DMN as a function of increased task demand. Fifty healthy adult subjects performed two distinct functional magnetic resonance imaging tasks that were designed to reliably map deactivations from a resting baseline. As primary findings, increases in task demand consistently modulated the regional anatomy of DMN deactivation. At high levels of task demand, robust deactivation was observed in non-DMN regions, most notably, the posterior insular cortex. Deactivation of this region was directly implicated in a performance-based analysis of experienced task difficulty. Together, these findings suggest that task-induced deactivations from rest are not limited to the DMN and extend to brain regions typically associated with integrative sensory and interoceptive processes.

PMID:
21829564
[PubMed - indexed for MEDLINE]
PMCID:
PMC3146521
Free PMC Article
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