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Curr Opin Lipidol. 2011 Oct;22(5):365-72. doi: 10.1097/MOL.0b013e32834a77b4.

Macrophage polarization in metabolic disorders: functions and regulation.

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  • 1Univ Lille Nord de France, Inserm, U1011, Lille, France.

Abstract

PURPOSE OF REVIEW:

To discuss recent findings on the role and regulation of macrophage polarization in obesity and atherosclerosis.

RECENT FINDINGS:

Macrophages infiltrate the vascular wall during atherosclerosis and adipose tissue during obesity. At least two distinct subpopulations with different functions, the classically (M1) and the alternatively (M2) activated macrophages, have been found in these tissues. Reciprocal skewing of macrophage polarization between the M1 and M2 states is a process modulated by diet, humoral and transcription factors, such as the nuclear receptor peroxisome proliferator-activated receptor gamma.

SUMMARY:

Recent literature highlights the importance not only of the number of infiltrated macrophages, but also their activation in the maintenance of the inflammation state. Identifying mechanisms and molecules able to modify the balance between M1 and M2 represents a promising field of research.

PMID:
21825981
[PubMed - indexed for MEDLINE]
PMCID:
PMC3565956
Free PMC Article
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