Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Vaccine. 2011 Oct 6;29(43):7535-41. doi: 10.1016/j.vaccine.2011.08.012. Epub 2011 Aug 4.

Different influenza vaccine formulations and adjuvants for childhood influenza vaccination.

Author information

  • 1Department of Maternal and Pediatric Sciences, Universit√† degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milan, Italy. susanna.esposito@unimi.it

Abstract

Pediatric influenza is a very common disease: attack rates range from 23% to 48% during interpandemic years and are significantly higher during pandemics. Influenza-related complications seem to be more common in children at risk because of an underlying chronic severe disease, but recently collected data clearly demonstrate that otherwise healthy children can also suffer from severe influenza and that the annual number of deaths is no different between the two groups. The aim of this review is to discuss the characteristics of all influenza vaccines in order to evaluate the real likelihood of prevention, as well as the safety and tolerability of the different formulations and adjuvants. The data indicate that further studies collecting efficacy and effectiveness data and evaluating the immunogenicity and safety of the different formulations and adjuvants should lead to the identification of more ideal influenza vaccines that could be used with significant advantage in the entire pediatric population.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21820478
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk