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Immunity. 2011 Aug 26;35(2):208-22. doi: 10.1016/j.immuni.2011.06.003. Epub 2011 Aug 4.

T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis.

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  • 1Centro de Biologia Molecular Severo Ochoa, CSIC-UAM, 28049 Madrid, Spain.

Abstract

The immunological synapse (IS) serves a dual role for sustained T cell receptor (TCR) signaling and for TCR downregulation. TC21 (Rras2) is a RRas subfamily GTPase that constitutively associates with the TCR and is implicated in tonic TCR signaling by activating phosphatidylinositol 3-kinase. In this study, we demonstrate that TC21 both cotranslocates with the TCR to the IS and is necessary for TCR internalization from the IS through a mechanism dependent on RhoG, a small GTPase previously associated with phagocytosis. Indeed, we found that the TCR triggers T cells to phagocytose 1-6 μm beads through a TC21- and RhoG-dependent pathway. We further show that TC21 and RhoG are necessary for the TCR-promoted uptake of major histocompatibility complex (MHC) from antigen-presenting cells. Therefore, TC21 and RhoG dependence underlie the existence of a common phagocytic mechanism that drives TCR internalization from the IS together with its peptide-MHC ligand.

Copyright © 2011 Elsevier Inc. All rights reserved.

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PMID:
21820331
[PubMed - indexed for MEDLINE]
PMCID:
PMC4033310
Free PMC Article
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