Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Bioessays. 1990 Jan;12(1):14-21.

Functional and dynamic aspects of the mammalian nucleolus.

Author information

  • 1Institute of Zoology I, University of W├╝rzburg, Federal Republic of Germany.


Nucleoli are the sites of ribosome biogenesis. Transcription of the ribosomal RNA genes as well as processing and initial packaging of their transcripts with ribosomal and non-ribosomal proteins all occur within the nucleolus in an ordered manner and under defined topological conditions. Components of the nucleolus have been localized by immunocytochemistry and their functional aspects investigated by microinjection of antibodies directed against the enzyme responsible for rDNA transcription, RNA polymerase I. The role of nascent transcripts in postmitotic formation of nucleoli will be discussed.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk