Self-assembled antimicrobial and biocompatible copolymer films on titanium

Macromol Biosci. 2011 Nov 10;11(11):1515-25. doi: 10.1002/mabi.201100124. Epub 2011 Aug 4.

Abstract

Copolymers of 4-vinyl-N-hexylpyridinium bromide and dimethyl(2-methacryloyloxyethyl) phosphonate self-assemble to form ultrathin layers on titanium surfaces that show antimicrobial activity, and biocompatibility. The copolymer layers are characterized by contact angle measurements, ellipsometry and XPS. Antibacterial activity is assessed by investigation of adherence of S. mutans. Biocompatibility is rated based on human gingival fibroblast adhesion and proliferation. By balancing the opposing effects of the chemical composition on biocompatibility and antimicrobial activity, copolymer coatings are fabricated that are able to inhibit the growth of S. mutans on the surface but still show attachment of gingival fibroblasts, and therefore might prevent biofilm formation on implants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / chemical synthesis*
  • Anti-Infective Agents / metabolism
  • Anti-Infective Agents / pharmacology
  • Cell Adhesion / drug effects
  • Cell Proliferation / drug effects
  • Cells, Cultured
  • Coated Materials, Biocompatible / chemical synthesis*
  • Coated Materials, Biocompatible / metabolism
  • Coated Materials, Biocompatible / pharmacology
  • Dental Implants
  • Fibroblasts / cytology
  • Fibroblasts / drug effects
  • Gingiva / cytology
  • Gingiva / drug effects
  • Humans
  • Magnetic Resonance Spectroscopy
  • Methacrylates / chemical synthesis*
  • Methacrylates / metabolism
  • Methacrylates / pharmacology
  • Microscopy, Atomic Force
  • Photoelectron Spectroscopy
  • Polymers / chemical synthesis*
  • Polymers / metabolism
  • Polymers / pharmacology
  • Pyridinium Compounds / chemical synthesis*
  • Pyridinium Compounds / metabolism
  • Pyridinium Compounds / pharmacology
  • Streptococcus mutans / drug effects*
  • Streptococcus mutans / growth & development
  • Surface Properties
  • Titanium / chemistry*

Substances

  • Anti-Infective Agents
  • Coated Materials, Biocompatible
  • Dental Implants
  • Methacrylates
  • Polymers
  • Pyridinium Compounds
  • Titanium