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J Drugs Dermatol. 2011 Aug;10(8):831-4.

Yin-yang strategy: proposing a new, effective, repeatable, sequential therapy for psoriasis.

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  • 1University of California San Francisco, Psoriasis and Skin Treatment Center, San Francisco, CA 94118, USA.


Psoriasis is a chronic disease that exists in two phases: (1) the acute, flaring phase when psoriasis is highly inflamed, erythematous and pruritic and (2) the chronic, indolent phase after the acute manifestations are brought under control. Ideal therapies for psoriasis must focus on both of these phases. Therefore, a rapid and effective agent must be utilized to treat the acute phase, followed by safe long-term therapy for maintenance. This article proposes a new, effective sequential topical therapy for psoriasis using ongoing treatment with clobetasol (Clobex®) spray for one month followed by calcitriol (Vectical®) ointment for the next month. This strategy provides a highly effective, reliable and safe treatment option with minimal local and systemic adverse risks.

[PubMed - indexed for MEDLINE]
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